NEDD4L and hyperinsulinemic hypoglycemia, familial, 4: However, after 12 weeks of Nedd4-2 deficiency, the volume of AE2 cells (42.2 (11.3) mm3 vs. 17.1 (3.2) mm3, p = 0.021) and the volume of lamellar bodies per lung (8.38 (1.64) mm3 vs. 3.56 (1.11) mm3, p = 0.014) were larger in males compared to females.