We have used an integrated computational approach to explore structural transition which is imposed by nine mutations, namely, D835A, D835E, D835F, D835G, D835H, D835I, D835N, D835V, and D835Y, on the native FLT3 structure and its interaction with type-I and type-II AML inhibitors. This evidence concerns the gene FLT3 and acute myeloid leukemia.