ESPL1 and neoplasm: For the genes with known roles in tumour suppression (e.g., LRRC4C, ERGIC2, GJA9, PHLPP2, and SERPINI2) or oncogenic function if upregulated (e.g., KLC2, P2RY2, ESPL1, INF2, ARHGAP33, ENPP3, and FAM166B), we report the gene expression values of the three primary tumours and recurrent tumour (Supplementary Table S2a), but we did not observe evident differences between them.