Consistent with a proposed role of ERK5, KLF2, and KLF4 in atheroprotection, various mouse models of atherosclerosis further established a key role of the ERK5/KLF2/KLF4 cascade as a flow-regulated signaling module that safeguards from atherosclerosis [61,62,63]. The gene discussed is KLF4; the disease is atherosclerosis.