A cardioprotective effect of the ERK5/MEF2 module is also supported by the observations that metabolic stress-induced cardiomyopathy was associated with decreased expression of ERK5, MEF2A, and MEF2D, and that the specific conditional deletion of Erk5 in cardiomyocytes intensified this metabolic-induced cardiomyopathy [104]. The gene discussed is MEF2D; the disease is cardiomyopathy.