Conversely, Lee et al. recently reported that expression of miR211, a micro RNA suppressing expression of the ERK5-specific dual specificity phosphatase DUSP6, which removes phosphorylation at the MEK5-targeted TEY motif of ERK5, led to an increased ERK5 basal phosphorylation, and thereby augmented the tumor growth of BRAF mutant melanoma cells in vivo and their resistance to the BRAFi vemurafenib in vitro [121]. This evidence concerns the gene MAP2K5 and melanoma.