MYOC and vascular insufficiency disorder: The multifactorial pathobiology of elevated IOP and RGC death is complex and involves changes in connective tissue composition and biomechanical support, blood flow and vascular insufficiency [6,7], metabolic and oxidative stress [8,9,10], neuroinflammatory and immune mechanisms [11,12], but also genetic factors [13], such as mutations in the myocilin (MYOC) gene [14].