Analysis of the RGC density between naive eyes and eyes exposed to ocular hypertension for three weeks does not indicate significant differences in the periphery (Ad5.MYOC: 2093 ± 311 Brn3a+ cells/mm2 vs. naïve controls: 2153 ± 461 Brn3a+ cells/mm2, p = 0.99), mid-periphery (Ad5.MYOC: 3128 ± 279 Brn3a+ cells/mm2 vs. naïve controls: 3396 ± 599 Brn3a+ cells/mm2, p = 0.74) and central area of the retina (Ad5.MYOC: 3621 ± 126 Brn3a+ cells/mm2 vs. naïve controls: 3851 ± 292 Brn3a+ cells/mm2, p = 0.84, Figure 2B). Here, MYOC is linked to ocular hypertension.