Using RNA sequencing, Nattkemper et al. found there was no significant difference in the levels of Trpv4 mRNA in pruritic, lesional skin versus non-pruritic, non-lesional skin for neither atopic dermatitis nor psoriasis patients, but there was a significant increase in pooled pruritic, lesional skin of atopic dermatitis and psoriasis patients versus healthy controls [57]. Here, TRPV4 is linked to psoriasis.