TRPV4 and atopic eczema: Interestingly, the contribution of warm temperatures to itch perception via keratinocyte TRPV4 has been demonstrated: Sanders et al. recently reported that innocuous warmth of the skin significantly increased 5-HT-evoked scratching and spontaneous scratching in the ovalbumin model of atopic dermatitis but decreased histamine-evoked scratching, which was blocked by TRPV4 selective antagonist GSK205 [30].