In leukemia-associated genomic rearrangements, RUNX1 may either represent a C-terminal fusion partner—for example, in ETV6-RUNX1-positive B-ALL—or it may be N-terminally fused to proteins, such as eight-twenty-one family members (RUNX1T1, CBFA2T2, CBFA2T3) in AML [24,25,26]. This evidence concerns the gene RUNX1 and precursor B-cell acute lymphoblastic leukemia.