Angiogenesis is important to ensure a continuous supply of essential nutrients and oxygen for cancer cells via expression of various pro-angiogenic factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2), fibroblast activation protein (FAP), and chemokine 12 (CXC12), which are maintained by CAFs via a secretome dependent manner [97]. The gene discussed is VEGFA; the disease is cancer.