CAFs mediate migration and invasion of the cancer cells via altering the architecture of TME by various actions, including secretion of ECM (fibronectin and collagen type I, II), growth factors and cytokines (such as TGF-β, HGF, FGF, CXCL12, CCL2, CCL5, CCL7, CXCL16, and IL-6) [81,82,83], generation of escaping paths (via MMP, RhoA, ROCK, and MyoII) [84], and modification of the tumor ECM architecture and fibre alignment (via FAP, Cav1, SNAIL1, TWIST1, palladin, and mechanical force) [85,86,87]. This evidence concerns the gene FAP and cancer.