Another study showed that KLF15 can activate twist-related protein 2 (TWIST2) to ameliorate liver steatosis and inflammation by modulating nuclear factor (NF)-κB or sterol regulatory element-binding protein 1c (SREBP1c)-fibroblast growth factor 21 (FGF21) signaling pathways [25]. The gene discussed is TWIST2; the disease is Hepatic steatosis.