In contrast, long-term activation of p53 with low-dose of doxorubicin showed a beneficial effect on the HFD-induced murine NAFLD model, including reduction of lipogenesis, inflammation, and endoplasmic reticulum (ER) stress [43], which was abrogated in liver-specific p53 deficiency mice. The gene discussed is TP53; the disease is metabolic dysfunction-associated steatotic liver disease.