It is known that the renal expression of the main proinflammatory cytokines—such as IL-1β, IL-6, and IL-18, as well as TNF-α—by glomerular resident and interstitial cells in the renal tissue of patients with DN are increased [6,59,60], and kidney DCs can be activated by these cytokines released from these cells. The gene discussed is IL1B; the disease is liver dysplastic nodule.