In addition, other epigenetic modification enzymes, HDAC1, 2, and 4 SIRT1, LSD1, and KDM3A are decreased, whereas CREBBP, PCAF, SETD1A, MLL, STEDB1, and SUV39H2 are increased in IgA vasculitis, suggesting that these epigenetic modification enzymes might organize DNA and histone modifications in patients with IgA vasculitis and exacerbate inflammatory responses [143]. The gene discussed is SETD1A; the disease is Henoch-Schoenlein purpura.