These findings suggest that CurLIP formulation may represent a novel strategy for re-establishing the tissue homeostasis through the modulation of TLR4/MyD88/NFkB/NLRP3/Caspase-1/IL-1β signaling cascade in an in vitro model of hPDLSCs and e-hPDLSCs exposed to LPS-G stimulus and may be considered as a promising molecule to be used alone or in combination therapy for the periodontal disorder. This evidence concerns the gene NLRP3 and periodontal disorder.