We found that the eyes of IL-27Rα−/− mice exhibited more severe vasculitis/retinitis and perivascular exudates by day 21 at the peak of EAU, WT littermates developed focal lesions around optic nerve and less inflammatory exudates at the same time, and naïve WT mice served as the healthy control (Figure 1B). This evidence concerns the gene IL27RA and vasculitis.