For a long time, sporadic CRC has been perceived as a homogenous condition that occurs with the adenoma-carcinoma phenotype, which is caused by many genetic alterations of CRC key genes, such as KRAS, tumor suppressor protein (TP) 53, and APC Regulator Of WNT Signaling Pathway (APC) [4]. This evidence concerns the gene TCHP and colorectal carcinoma.