Western blot analysis of tumor samples collected from all groups demonstrated the phosphorylated, and of non-phosphorylated protein levels expression of oncogenic markers (p-EGFR), p-ERK, p-MEK, c-RAF/BRAF and p-c-RAF/BRAF (Figure 6C), whereas the qRT-PCR analysis of blood-plasma levels showed the highest level of miR-193a-3p expression in combination-treated pooled blood samples, followed by 4-AAQB, cetuximab, and vehicle control (Figure 6D). Here, RAF1 is linked to neoplasm.