STAT6 and neoplasm: In the report presented here, we describe a tumor lesion that exhibits histological features of SFT, exhibits nuclear positivity for STAT6 and carries a gene fusion, affecting STAT6 and the NFIX gene, another partner gene that is different than NAB2. The discovery of a new fusion partner in SFT opens intriguing new ways to refine the role of STAT6 in the sarcomatogenesis of this entity.