In addition to IFN-γ, we have previously demonstrated, in a number of cell types [20,23], that EMILIN-2 elicits the expression of IL-8, a paradigmatic cytokine in the crossroads between angiogenesis and inflammation [35,36,37], and that the low expression of EMILIN-2 characterizing some melanoma patients may result in altered activation of the two processes. The gene discussed is EMILIN2; the disease is melanoma.