Since psoriasis and IBDs are both chronic diseases based on a persistent inflammatory state that can be counteracted using similar biological drugs, we have extended the previous data from Marafini et al. testing these AhR ligands on two different three-dimensional (3D) models of psoriasis: a reconstructed human epidermal equivalent (HEE) and a full-thickness reconstructed skin which represents a more complex system due to the presence of psoriatic fibroblasts. This evidence concerns the gene AHR and psoriasis.