Therefore, the aim of this study was to characterise the expression of SPINT2 at the mRNA and protein level in placental and plasma samples from pregnancies that have been affected by preeclampsia and/or FGR, as well as in a rodent model of placental insufficiency, and to observe any hypoxic- or inflammation-mediated changes in expression in vitro. Here, SPINT2 is linked to placental insufficiency.