In placentas affected concurrently with preeclampsia and FGR (median = 195.4 pg/mL, IQR: 157.0–232.8 pg/mL), SPINT2 was significantly elevated (p = 0.0171) compared to the controls (median = 157.6 pg/mL, IQR: 118.4–183.5 pg/mL), with a similar result observed in the placentas from pregnancies that were affected by preeclampsia alone (p = 0.0042, median = 189.9pg/mL, IQR: 165.6–226.3 pg/mL). Here, SPINT2 is linked to preeclampsia.