In contrast, the placentas from pregnancies that were complicated by both preeclampsia and FGR (n = 20) had significantly decreased SPINT2 mRNA expression (68% of control, p = 0.002), whereas those affected by preeclampsia only (n = 60) had significantly increased SPINT2 mRNA levels (119% of control, p = 0.03). This evidence concerns the gene SPINT2 and preeclampsia.