GAD1 and schizophrenia: Quantification of GAD67 and Zif268 mRNA levels in dorsolateral pre-frontal cortex area in patients with schizophrenia and healthy comparison using polymerase chain reaction showed an altered expression of the transcriptional regulatory factor Zif268 in schizophrenia subjects that may provide a potential mechanistic basis for impaired GABA synthesis in the illness [98].