MAPT and early-onset autosomal dominant Alzheimer disease: The most common trait involved in the etiology of neurological disorders like Alzheimer’s disease and Parkinson’s disease includes the aggregation of toxic misfolded proteins, which leads to synaptic dysfunction and the destruction of neurons [46] For instance, the extracellular β-amyloid plaques observed in Alzheimer’s disease in conjunction with intracellular neurofibrillary tangles formed by the hyperphosphorylation of the tau protein is the contributing factor in the pathophysiology of Alzheimer’s disease [47].