In addition, it has been found that mutations in the CDKN1C sequence in humans are responsible for the pathogenesis of growth disorders, such as Beckwith–Wiedemann (BWS), IMAGe (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies), and Russell–Silver (RSS) syndromes [19]. This evidence concerns the gene CDKN1C and Beckwith-Wiedemann syndrome.