Viral titer measurements showed that increasing the amounts of GPC, 2-OH-Ade, and γ-GC did not significantly affect the replication of BmNPV in BmE cells, while 4-hydrotobutamide inhibited the infection of BmNPV at 2.5 μM and promoted the proliferation of BmNPV at 20 μM. The gene discussed is GYPC; the disease is infection.