According to the findings, the IL-1β, IL6, and IL-8 levels of the 63 cases with incident depression increased; however, the comparative analytics among the IL-1β, IL-6, and IL-8 levels of the cases with incident depression at baseline and those with no incident depression at baseline failed to present a significant difference (χ2 = 0.544; p-value = 0.461). The gene discussed is CXCL8; the disease is major depressive disorder.