Molecular genetic analysis of mesothelioma revealed frequent copy number loss and recurrent somatic mutations in TSGs such as BRCA1-associated protein 1 (BAP1, 60% of the cases), neurofibromin 2 (NF2, 75% of the cases), and cyclin-dependent kinase inhibitor 2A (CDKN2A, 60% of the cases) [16]. The gene discussed is NF2; the disease is mesothelioma.