The tumour-suppressing functions of BAP1, KAP1, TP53, LATS2, SETD2, USP49 and PRMT6, some of which are the genes participating in histone modification and regulation, were also lost in mesothelioma [15,16,161,162,163,164,165,166,167], indicating that the inactivation of histone-modifying genes plays a crucial role in the occurrence and metastasis of mesothelioma [161]. The gene discussed is SETD2; the disease is mesothelioma.