SETDB1 and mesothelioma: Moreover, a study of germline mutations in 101 mesothelioma patients suggested that germline missense variants in SETD2 and SETDB1 may be associated with predisposition for mesothelioma [17], and frequent inactivating mutations of SETDB1 were found in 78 primary mesothelioma tissues from 69 patients (mutation frequency: 10%, 7/69), indicating the important role of SETDB1 in mesothelioma [18].