For example, the expression of Tp53 in pancreatic ductal adenocarcinomas [109,110] and colorectal cancer [14,21,110,111], p16-INK4A in melanomas [112], p53BP2 in hela cell line of cervical cancer [1], APOE, and HoxA in lung cancer [21], as well as RASSF1A in breast cancer cells [72], are all repressed by SETDB1. This evidence concerns the gene RASSF1 and breast carcinoma.