A total of 9 genes (TP53, KMT2D, KMT2C, neurotrophic receptor tyrosine kinase 1 (NTRK1), ATM, NOTCH3, Janus Kinase 3 (JAK3), G-protein alpha stimulatory subunit (Gsα subunit) (GNAS), and APC membrane recruitment protein 1 (AMER1)) were found mutated in both cirrhotic/advanced fibrotic subjects and HCC patients. This evidence concerns the gene KMT2C and hepatocellular carcinoma.