ESR1 and colorectal cancer: Other top canonical pathways included colorectal cancer metastasis signaling (p = 2.74 × 10−8), pancreatic adenocarcinoma signaling (p = 1.70 × 10−9), and IL-15 production (p = 1.54 × 10−12), while predicted upstream regulators included interferon gamma (p = 1.95 × 10−6), estrogen receptor (p = 4.09 × 10−7), miR-125b-5p (p = 2.98 × 10−8), and mir-10 (p = 2.14 × 10−8) (Figure 5D).