It was previously suggested that DNA damage repair signaling is essential for the maintenance of stem cell pluripotency in HCC [65] and that p38 MAPK signaling, leading to F-actin reorganization and activation of nuclear factor erythroid 2-related factor 2-mediated oxidative stress response, collectively contribute to enhanced stemness of HCC cells [66]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.