Genes found mutated in the cfDNA of Hispanic HCC patients included frequently identified HCC driver mutations, such as TP53, CTNNB1, AXIN1, RB transcriptional corepressor 1 (RB1), AT-rich interaction domain 1A (ARID1A) and 2 (ARID2), SWI/SNF related matrix-associated actin-dependent regulator of chromatin, subfamily A member 4 (SMARCA4), and NFE2L2 [32,36], with TP53 being the most commonly mutated gene. The gene discussed is RB1; the disease is hepatocellular carcinoma.