EMILIN1 and melanoma: Importantly, analysis of EMILIN-1 expression by Western-blot using specific antibodies [19] in mouse melanoma models demonstrated that it is not detected intracellularly in any of the tested cell lines but interestingly it is secreted in sEVs derived from LN metastatic model B16-F1R2 (Figure 2B, left panels, cells), which let us hypothesize that EMILIN-1 could be detected extracellularly in sEVs.