IL-10-/- mice fed with standard chow diet containing piroxicam for 10 days developed colitis characterized by a significant body weight loss (Figure 1a) and severe macroscopic (Figure 1b–d) and microscopic (Figure 1e,f) colonic lesions as compared to age-matched IL-10-/- mice fed with standard chow diet free of piroxicam. Here, IL10 is linked to colitis.