Much remains to be understood regarding heart failure and its treatment by targeting receptors (e.g., angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor-neprilysin inhibitors (ARNIs), β-adrenergic receptor blockers, and α-adrenergic receptor blockers), guanylate cyclase stimulators, and CaMKIIδ inhibitors [218,219]. Here, ACE is linked to heart failure.