TNF and rheumatoid arthritis: Moreover, Takahashi et al., using capillary electrophoresis–time-of-flight mass spectrometry (CE–TOFMS), identified betonicine, glycerol 3-phosphate, N-acetylalanine, hexanoic acid and taurine as serum biomarkers able to predict a response in RA patients receiving anti-TNF therapy [24].