Future therapies in the field of colorectal cancer may also involve genome editing technologies to remove harmful “driver mutations” and insert “preventive mutations” using zinc-finger nucleases, transcription-like effector nucleases, and short palindromic repeat-associated nuclease 9 [153] in CXCL12–CXCR4/CXCR7 axis and its modulators. This evidence concerns the gene CXCL12 and colorectal cancer.