Recent review articles related to C-X-C motif chemokine ligand 12 (CXCL12)-chemokine receptor type 4 (CXCR4)/ chemokine receptor type 7 (CXCR7) axis are focused on cancers in general, however, our focus in this review is to summarize the role of this axis in CRC progression and metastasis. The gene discussed is CXCR4; the disease is cancer.