Song ZV et al. documented that villin-dependent CXCR7–CXCR4 up-regulated mice exhibited more severe colitis and tumorigenesis than villin-CXCR4 or villin-CXCR7 alone up-regulated mice when exposed to dextran sodium sulfate (DSS) [99]. The gene discussed is CXCR4; the disease is colitis.