PINK1 and breast carcinoma: For instance, the dysregulated expression of nuclear genes such as dynamin 1 such as (DRP1), mitofusin 1 (MFN1) and 2 (MFN2) mitochondrial fusion and fission proteins, BCL2 inter-acting protein 3 (BNIP3), PTEN-induced kinase 1 (PINK1) and hypoxia inducible factor 1 (HIF1), observed in lung, bladder and breast cancers, suggests increased mitochondrial dynamics [111,112].