For example, MT-ND5 is mutated in many types of cancer, NADH: ubiquinone oxidoreductase core subunit 4 (MT-ND4) is frequently mutated in lung and prostate cancer, and Cytochrome c oxidase I (MT-CO1) is mutated in breast tumors [14,88]. The gene discussed is MT-CO1; the disease is prostate carcinoma.