BCHE and Alzheimer disease: For example, on the one hand, if most cases of AD involve a relative excess of NE and a relative deficiency of 5HT, DA, ACH, and MT, then a noradrenergic transmission reducing drug (clonidine, guanfacine, dexmedetomidine, propranolol, carvedilol, nebivolol, prazosin, doxazosin, or terazosin) could be paired with a 5HT boosting drug (SSRIs, phenelzine, tranylcypromine, or possibly clomipramine), or an ACH boosting compound (cholinesterase inhibitors), or MT.