Interestingly, the proportion of very-long-chain ceramides is also decreased in the epidermis of psoriatic lesions [94] and is associated with increased ACOX1 [38] and PPARδ (see above), thus corroborating the key role of the PPARδ pathway in lipid abnormalities in both lesional atopic dermatitis and psoriasis. This evidence concerns the gene PPARD and atopic eczema.