In a mouse model of dermatitis (i.e., mice topically treated with oxazolone, a chemical inducing Th2-predominant inflammation in mouse skin), topical application of GW1514, a PPARδ agonist, reduced epidermal hyperplasia, KC proliferation, transepidermal water loss, skin surface pH, skin infiltration by eosinophils and mast cells, and serum CCL17 [102]. The gene discussed is PPARD; the disease is dermatitis.