ATF3 and cancer: Figure 2a (right) shows an example of cancer cells either inside the blood vessel or outside (in the lung parenchyma). Images from all four groups of lungs were coded, pooled, reshuffled, and scored in a blind manner. As shown in Figure 2a (left), CTX did not affect extravasation in either WT or Atf3 KO lungs. However, the host Atf3 enhanced extravasation, as evidenced by the higher percentage of extravasated cells in WT than Atf3 KO lung. Thus, the Atf3 KO lung is less conducive for cancer cells to extravasate.