Comparing patients with a mutation in EGFr domains 1–6 with patients with a mutation in EGFr domains 7–34 in the DCR, the former had an earlier diagnosis of the disease, a significantly higher WMH load, and a similar trend in the number of subcortical infarcts, and a first stroke at 55 years of age, with a mean survival time of 69 years (as opposed to patients with mutations in EGFr domains 7–34 who have their first stroke at the age of 67 and a mean survival time of 77 years) [17,18]. Here, EGFR is linked to Stroke.