Although menin has been found to regulate cell proliferation in hepatocellular carcinoma [40], the exact role of menin in liver carcinogenesis has not yet been widely studied, and the liver is not a site of primary tumor development in MEN1 syndrome, but only metastases from pancreas and duodenal MEN1-related neuroendocrine tumors. The gene discussed is MEN1; the disease is multiple endocrine neoplasia type 1.