The interaction of these three miRNAs with MEN1 and menin protein should be functionally investigated, to better understand the exact role of these epigenetic regulators in the development and progression of parathyroid tumors, including their possible role in parathyroid carcinoma, which is extremely rare in MEN1 patients and appeared not to be directly correlated with the MEN1 mutation. This evidence concerns the gene MEN1 and tumor of parathyroid gland.