Increasing studies have linked miRNAs to autophagic regulation during cancer initiation (such as miR-224 targeting SMAD Family Member 4 (SMAD4) in hepatocellular carcinoma (HCC)) and cancer development (e.g., miR-224-3p targeting RB1-inducible coiled-coil protein (RB1CC1) in cervical tumors) [84]. This evidence concerns the gene RB1CC1 and cancer.