miR-145 has been recognized to act as an oncosuppressor miR, having shown to be involved in tumor invasion and progression by targeting C-MYC, Astrocyte Elevated Gene-1 (AEG-1), Epidermal Growth Factor Receptor (EGFR), Nudix Hydrolase 1 (NUDT1), and Octamer-binding transcription factor 4 (OCT4) in LAC [87]. The gene discussed is MTDH; the disease is neoplasm.