In fact, the relevance of miR-29s was discovered after its reinforced expression in NSCLC cell lines restored the normal patterns of DNA methylation, inducing the re-expression of methylation-silenced tumor-suppressor genes, such as Fragile Histidine Triad Diadenosine Triphosphatase (FHIT) and WW Domain Containing Oxidoreductase (WWOX), and inhibiting tumorigenicity in vitro and in vivo [92]. This evidence concerns the gene FHIT and non-small cell lung carcinoma.