Several roles have been hypothesized for CD34+SCs/TCs, including intercellular communication, control and organization of the extracellular matrix, structural support, endocytosis, creation of tissular microenvironments, guidance to migration, contribution of scaffolds, immunomodulation, neurotransmission, control and regulation of other cell types, stem cell modulation and participation in regeneration, repair and tumor stroma formation [1,2,3,13,15,19,20,21,22,23,24,25,26,27,28,29,30,31]. The gene discussed is CD34; the disease is neoplasm.