In 1993, Liu and colleagues identified that the recurrent balanced chromosomal rearrangement inv(16)(p13q22) and its variant t(16;16)(p13;q22) in AML lead to fusion of genes coding for the transcriptional coactivator core-binding factor β CBFB and smooth muscle myosin heavy chain MYH11, resulting in the formation of CBFB–MYH11 chimera [204]. This evidence concerns the gene MYH11 and acute myeloid leukemia.