The most common balanced rearrangements (chromosomal aberrations with no loss or gain of genetic material) in AML are t(15;17)(q22;q21) PML–RARA, t(8;21)(q22;q22) RUNX1–RUNX1T1, t(11;v)(q23;v) MLL-r, and inv(16)(p13q22) core-binding factor β (CBFβ)–smooth muscle myosin heavy chain (SMMHC, also known as myosin 11) (CBFB–MYH11). The gene discussed is CBFB; the disease is acute myeloid leukemia.