A recent analysis by The Cancer Genome Atlas (TCGA) revealed that 93% of colorectal cancers (CRC) have genetic alterations of the WNT signaling pathway, which have been identified as biallelic inactivation mutations of APC regulator of WNT signaling pathway (APC), a negative regulator of β-catenin/CTNNB1, or activating mutations of CTNNB1 in approximately 80% of the cases [1]. The gene discussed is CTNNB1; the disease is colorectal carcinoma.