REN and obesity due to melanocortin 4 receptor deficiency: Given the location of PRAT between the renal fascia and renal capsule, significant amounts of PRAT might activate the renin–angiotensin system in hypertensive and obese rabbits by applying physical pressure to the surrounding blood vessels, exacerbating obesity-related metabolic disorders, such as hypertension, insulin resistance, and atherosclerosis [12].