KEAP1 and obesity due to melanocortin 4 receptor deficiency: Moreover, mice with hypomorphic Keap1 alleles and resulting Nrf2 activation were partially protected from obesity and more glucose tolerant, which was attributed to a lower expression of gluconeogenic and lipogenic genes mediated by Nrf2-activated adenosine monophosphate (AMP)-activated protein kinase (Ampk) signaling [46].