Recently, in the Iceland population, Olafsdottir and coworkers [77], revealed an association of rs3820282 (in an intron of WNT4, probably encompassing the response to estrogen signaling) with Pelvic Organe Prolapse, thus allying this gene with endometriosis, leiomyoma, gestational duration, and as mentioned above, up to the early stages of female sex determination [50]. The gene discussed is WNT4; the disease is endometriosis.