For example, α-synuclein (α-syn) accumulates in Parkinson’s disease (PD), Aβ and tau proteins form aggregates in Alzheimer’s disease (AD) and related tauopathies, and transactive response DNA-binding protein of 43 kDa (TDP-43) aggregates in amyotrophic lateral sclerosis (ALS) [41]. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.