For instance, deletion of either Tsc1 or Tsc2 in differentiated astrocytes did not produce tuber-like lesions (and nevertheless resulted in seizures), but inactivation of Tsc1 or Tsc2 in undifferentiated radial glia cells early during development resulted in phenotypic neuropathological features characteristic for TSC patients, including aberrations in cortical cytoarchitecture as well as epileptic seizures ([100], for review [101]). This evidence concerns the gene TSC2 and tuberous sclerosis.