The link between NED, cGAS activation, and lipodystrophy is not yet known, but in the case of some Lamin A mutations such as HGPS and EDMD, it was demonstrated that the NE can collapse [68,80], highlighting a probable role of NE fragility and plausible NED and cGAS activation in the development of such clinical outcomes. This evidence concerns the gene LMNA and lipodystrophy.