LMNA and Emery-Dreifuss muscular dystrophy: To date, nearly 500 mutations have been identified in LMNA, which cause a plethora of diseases such as Emery–Dreifuss Muscular Dystrophy (EDMD), dilated cardiomyopathy (DCM), Hutchinson–Gilford Progeria Syndrome (HGPS), Lipodystrophy syndrome, and peripheral neuropathy.