Interestingly, a recent study of methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA transcriptome sequencing (RNA-seq) showed that AlkB homolog 5 (ALKBH5)-dependent high-mobility group box 1 (HMGB1) expression mediates the stimulator of interferon genes protein (STING)-IRF3 innate immune response in radiation-induced liver diseases, as unavoidable liver injury, which is the adverse effect for treatment of primary liver cancer [31]. The gene discussed is HMGB1; the disease is liver cancer.