H19 and type 2 diabetes mellitus: In addition, H19 depletion in HepG2 cells increased the nuclear localization of FoxO1 (an essential transcriptional factor in the regulation of gluconeogenesis and in the insulin response in the liver), impaired insulin signaling, and increased gluconeogenesis, suggesting the functional relevance of decreased H19 levels in the pathophysiology of T2D [57].