Further, it was connoted that CASC9, a hypoxia-inducible lncRNA, is regulated by HIF-1α and drives glycolysis via the upregulation of hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), and glucose transporter type 4 (GLUT4) levels in pancreatic cancer [49]. This evidence concerns the gene HK2 and familial pancreatic carcinoma.