In glioblastoma, it was identified that miR-449b-5p targets phosphatidylinositol 3-kinase enhancer (PIKE, also known as ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2)) [63], which possesses an anti-apoptotic activity [78,79]. The gene discussed is AGAP2; the disease is glioblastoma.