HP and hemolysis: In contrast, MARCO− macrophages display a pro-inflammatory transcriptional profile with decreased expression of CD 163, an anti-inflammatory scavenger receptor for hemoglobin-haptoglobin complexes that prevents intravascular oxidative stress damage from free hemoglobin, as it occurs in pathological conditions of intravascular hemolysis (malaria, hemoglobinopathies, autoimmune hemolysis, and drug-induced hemolysis) [33].